Marmara Pharmaceutical Journal 2018 , Vol 22 , Issue 2
Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation
Shima Azizi1,Arash Ghasemi2,Hossein Asgarian-Omran3,Zohreh Zal1,Azadeh Montazeri1,Hooman Yazdannejat1,Seyed Jalal Hosseinimehr1
1Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
2Department of Radiology and Radiation Oncology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
4Immunogenetics Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
DOI : 10.12991/mpj.2018.68 Radiotherapy is an important strategy for cancer treatment, but resistance of tumor cells to ionizing radiation (IR) still remains a main challenging issue related to radiotherapy. The aim of this study was to evaluate the sensitizing effect of cerium oxide nanoparticles (CNPs) on non-small lung cancer (A-549) cells exposure to IR. A-549 cells were treated with CNPs and exposed to IR at dose 2 Gy. The radiosensitizing effect of CNPs was evaluated by clonogenic assay and flowcytometry. The findings of this study showed that CNPs reduced the frequencies of A-549 colony when these cells were exposed to IR. CNPs treatment prior exposure to IR significantly increased the IR-induced apoptotic incidences in A-549 cells. The present study demonstrates that CNPs to be an effective sensitizer on apoptosis and cell death induced by IR in A-549 cells. Keywords : Cerium oxide nanoparticle, nanoceria, radiosensitizing, apoptosis, ionizing radiation, radiosensitizer