Marmara Pharmaceutical Journal 2017 , Vol 21 , Issue 4
The action of monoterpenoids with promising antiparkinsonian activity on fertility of Drosophila melanogaster
Maxim V. TRUSHIN1,Raisa G. KHAMIDULLINA1,Oleg V. ARDASHOV2,Konstantin P. VOLCHO2,Nariman F. SALAKHUTDINOV2
1Kazan Federal University, Institute of Fundamental Medicine and Biology, Kremlyovskaya 18, 420008 Kazan, Russia
2Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences, Lavrentjev av. 9, 630090, Novosibirsk, Russia
DOI : 10.12991/mpj.2017.29 Adequate treatment of Parkinson"s disease is an important medical issue. Patients are suffered from numerous side effects of the widely used drugs. It has been found recently that monoterpenoid (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl) cyclohex-3-ene-1,2-diol and its diacetate demonstrate high antiparkinsonian activity in some animal models. At the same time, their genetic safety was not studied yet. The aim of this research was to investigate the effect of these compounds with antiparkinsonian activities on reproduction of D. melanogaster. Over 4000 of fruitflies cultivated under the action of these compounds were analyzed. It was found that the chemicals did not provoke genetic mutations or alter reproduction of D. melanogaster. The possible explanations for the detected phenomena are provided. It was found that the compounds do not affect fertility in Drosophila.. Keywords : Parkinson