Marmara Pharmaceutical Journal 2017 , Vol 21 , Issue 4
Alkaloid Profiling of Galanthus woronowii Losinsk. by GC-MS and evaluation of its Biological Activity
Buket BOZKURT1,Ahmet EMİR1,Gülen İrem KAYA1,Mustafa Ali ÖNÜR1,Strahil BERKOV2,Jaume BASTİDA3,Nehir ÜNVER SOMER1
1Department of Pharmacognosy, Faculty of Pharmacy, Ege University, 35100, Izmir, Türkiye
2AgroBio Institute, 8 Dragan Tzankov Blvd., 1164-Sofia, Bulgaria
3Departament de Productes Naturals, Biologia Vegetal i Edafologia, Facultat de Farmacia, Universitat de Barcelona, Av. Diagonal 643, 08028 Barcelona, Spain
DOI : 10.12991/mpj.2017.12 The alkaloid profiles of the aerial parts and the bulbs of Galanthus woronowii Losinsk. were analyzed by means of Gas Chromatography-Mass Spectrometry (GC-MS). Totally, twentyeight compounds were detected. Galanthamine and galanthine were found to be the main alkaloids both in the extracts of the aerial parts and the bulbs. Most of the identified compounds were lycorine and galanthamine-type Amaryllidaceae alkaloids. In addition, the acetylcholinesterase (AChE) inhibitor potentials of the extracts prepared from the aerial parts and bulbs were determined by in vitro Ellman"s method and both of the extracts were found to exhibit significant activity (aerial parts: IC50= 0.027 μg/mL and bulbs: IC50= 0.084 μg/mL). Keywords : Galanthus woronowii; Amaryllidaceae; GC-MS; alkaloids