Marmara Pharmaceutical Journal 2017 , Vol 21 , Issue 4
The therapeutic effects of olive leaf extract on Leishmania major infection in BALB/c mice
Farnaz KHEIRANDISH1,Hossein MAHMOUDVAND1,Ali KHAMESIPOUR2,Farzad EBRAHIMZADEH3,Farnaz BEHRAHI4,Bahram DELFAN5
1Department of Parasitology and Mycology, School of Medicine, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
2Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
3Department of Biostatistics, School of Health and Nutrition, Lorestan University of Medical Sciences, P.O. Box 381351698, Khorramabad, Iran
4School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
5Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
DOI : 10.12991/mpj.2017.6 At present, no effective vaccine has been found for CL; thus, the upgrading and improvement of the present drugs and development of the novel agents have been demonstrated to be the merely control choice for this disease. The present study aims to evaluate the effects of olive leaf extract (Olea europaea L. OLE) on Leishmania major infection in BALB/c mice. OLE tested on cutaneous leishmaniasis (CL) in male BALB/c mice with L. major promastigotes (MRHO/IR/75/ER) at the doses of 10, 20, and 30 mg/kg. Results demonstrated that after treatment of the groups with the concentrations of 10, 20, and 40 mg/ kg of OLE, mean diameter of lesions was reduced by 2.16, 5.87, and 7.61 cm, respectively. Moreover, after 4 weeks of treatment, 83.3%, 66.64%, and 33.32% recovery was observed in the infected mice treated with 40, 20, and 10 mg/kg of OLE, respectively. In conclusion, the present study showed OLE has potent therapeutic effects on cutaneous leishmaniasis. Keywords : Olive; Leishmania; mice; cutaneous leishmaniasis; in vivo