Marmara Pharmaceutical Journal 2017 , Vol 21 , Issue 3
3D quantitatve structure activity relationship of tetrahydroimidazo [1,2-a] pyrimidine as antimicrobial agents
SA Khedkar1,JS Patil2,PM Sable3
1Department of Pharmaceutical Chemistry, College of Pharmacy, Akluj, Maharashtra, India
2Shivajirao Jondhale College of Pharmacy, Asangaon, India
3Rashtrasant Tukadoji Maharaj University, Nagpur, India
DOI : 10.12991/marupj.323296 A series 24 tetrahydroimidazo[1,2-a] pyrimidine derivatives were subjected to 3D quantitative structure activity relationship for antimicrobial activity. Partial least square methodology was utilized for the development of QSAR models. Six different QSAR models have been generated for antimicrobial efficiency of tetrahydroimidazo[1,2-a] pyrimidine derivatives against three human pathogens. QSAR models revealed positive influence of steric and electronic parameters on antimicrobial potential - of tetrahydroimidazo[1,2-a] pyrimidine derivatives. Keywords : Antimicrobial, Pyrimidine, QSAR, Partial least square