Marmara Pharmaceutical Journal 2017 , Vol 21 , Issue 3
Formulation and evaluation of a bilayer tablet comprising of diclofenac potassium as orodispersible layer and diclofenac sodium as sustained release core
Jabbar Abbas1,Sajid Bashir1,Muhammad Samie2,Sadaf Laghari3,Nargis Aman2,Habib Ullah Jan4,Imran Nazir2
1Institute of Pharmaceutical Sciences, People’s University of medical and health sciences for women, Shaheed Benazir Abad 67450 Pakistan
2Faculty of Pharmacy, University of Sargodha, Sargodha 40100 Pakistan
3Department of Pharmacy, Comsats institute of information technology, Abbottabad 22060 Pakistan
4College of Pharmacy, Liaqat University of Medical & Health Sciences, Jamshoro 76090 Pakistan
5Department of Pharmacy, Abdul Wali Khan University, Mardan 23200 Pakistan
DOI : 10.12991/marupj.323595 Diclofenac a phenylacetic acid derivative has long been used as an anti-inflammatory and analgesic drug to treat certain conditions however its sustained release formulation with immediate release loading dose is desirable. The rationale of the current work was to develop and evaluate bilayer tablets with diclofenac potassium as orodispersible layer and diclofenac sodium as sustained release core. The diclofenac sodium core was prepared by wet granulation method while the orodispersible outer layer was prepared by direct compression method using super disintegrant sodium starch glycolate. The powder blends were then evaluated for both pre- compressional and post compressional properties. The physical parameters of both powders and tablets were in accordance with the compendial standards. The orodispersible portion disintegrated in less than 30sec releasing diclofenac potassium as the loading dose while the core was able to sustain the release of diclofenac sodium up to 10hrs in simulated intestinal fluid (pH 6.8). The kinetic data revealed that the release pattern was best fitted into Korsmeyer-Peppas model with non-fickian release. The outer orodispersible layer of diclofenac potassium and sustained release inner core of diclofenac sodium in a single tablet was successfully formulated while sodium starch glycolate showed to have good super disintegrant properties. Keywords :