Marmara Pharmaceutical Journal 2017 , Vol 21 , Issue 3
Chemical Profile of Malva Neglecta and Malvella Sherardiana By Lc-Ms/Ms, Gc/Ms And Their Anticholinesterase, Antimicrobial and Antioxidant Properties with Aflatoxin-Contents
Nesrin Haşimi1,Abdulselam Ertaş2,Elif Varhan Oral3,Hüseyin Alkan4,Mehmet Boğa5,Mustafa Abdullah Yılmaz6, İsmail Yener3,Işıl Gazioğlu7,Cumali Özaslan8, Mehmet Akdeniz9,Ufuk Kolak10
1Department of Nutrition and Dietetics, School of Health, Batman University, Batman
2Department of Pharmacognosy, Faculty of Pharmacy, Dicle University, Diyarbakır
3Department of Analytical Chemistry, Faculty of Pharmacy, Dicle University, Diyarbakır
4Department of Biochemistry, Faculty of Pharmacy, Dicle University, Diyarbakır
5Department of Pharmaceutical Technology, Faculty of Pharmacy, Dicle University, Diyarbakır
6Research and Application of Science and Technology Center (DÜBTAM), Dicle University, Diyarbakır
7Deparment of Analytical Chemistry, Faculty of Pharmacy, Bezmialem Vakıf University, Istanbul
8Department of Plant Protection, Faculty of Agriculture, Dicle University, Diyarbakır
9Department of Chemistry, Diyarbakır Chairmanship, The Council of Forensic Medicine The Ministry of Justice, Diyarbakır
10Department of General and Analytical Chemistry, Faculty of Pharmacy, Istanbul University, Istanbul
DOI : 10.12991/marupj.307461 The purpose of the present work was to calculate the phenolic and the fatty acids profiles by LC-MS/MS and GC/MS with the antioxidant, anticholinesterase and antimicrobial activities, and aflatoxin contents of Malva neglecta and Malvella sherardiana. The phenolic composition of M. neglecta and M. sherardiana were determined by LC-MS/MS. In studied twenty seven compounds, malic and 4-OH benzoic acids were found to be the most abundant compounds in M. neglecta and M. sherardiana, respectively. On the other hand, essential ois and fatty acids composition were determined by GC/MS analysis. It is found that total flavonoid contents in methanol extracts were less than their total phenolic contents. The methanol extracts of the plants showed the highest effect in all antioxidant assays of this study. The methanol extract of M. neglecta showed the highest activity among all of the extracts against acetyl- and butyryl- cholinesterase enzymes. The acetone extracts of M. neglacta and M. sherardiana exhibited moderate activity against C. albicans. The results of the present study is also showed that the M. neglecta and M. sherardiana can also be used as a food source due to its high phenolic acid content and good antioxidant property. Also, the samples were aflatoxin free. Keywords : Anticholinesterase; antioxidant; Malva neglecta; Malvella sherardiana; LC-MS/MS, GC-MS